Up-regulation of A2B adenosine receptor in A2A adenosine receptor knockout mouse coronary artery
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چکیده
منابع مشابه
The A2A adenosine receptor mediates coronary vasodilation.
The coronary vasodilation caused by adenosine is due to activation of A2 adenosine receptors (A2AdoRs), but the subtype or subtypes of A2AdoR (A2A and/or A2B) that mediate this action are uncertain. The purpose of this study was to test the hypothesis that A2AAdoRs mediate coronary vasodilation caused by exogenous or endogenous adenosine in the guinea pig isolated perfused heart. The newly desc...
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BACKGROUND Adenosine is a potent coronary vasodilator and causes an increase of coronary blood flow by activation of A2A-adenosine receptors (A2A-AdoRs). The purpose of this study was to test the hypothesis that the high potency of adenosine and adenosine analogues to cause coronary vasodilation is explained by the presence of a large A2A-AdoR reserve ("spare receptors"). METHODS AND RESULTS ...
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Summary: Adenosine through adenosine receptor have a crucial role in biology of lung cancer. Recent study indicated adenosine receptors have a crucial role in various aspect of lung cancer from cell growth and metastasis to modulation of apoptosis and it could be considered as a potential candidate for treatment of the lung cancer.
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Zhan E, McIntosh VJ, Lasley RD. Adenosine A2A and A2B receptors are both required for adenosine A1 receptor-mediated cardioprotection. Am J Physiol Heart Circ Physiol 301: H1183–H1189, 2011. First published July 8, 2011; doi:10.1152/ajpheart.00264.2011.—All four adenosine receptor subtypes have been shown to play a role in cardioprotection, and there is evidence that all four subtypes may be ex...
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Background The A2A adenosine receptor has become a drug target in the treatment of Parkinson’s disease, psychotic behavior and dementia. In addition, targeted deletion of this receptor in mice leads to hypertension, increased platelet aggregation, male aggressiveness and decreased susceptibility to ischemic brain damage. The potential clinical relevance of this receptor is obvious. The A2A aden...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2008
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2008.03.003